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Abaloparatide
Also known as: Tymlos
FDA-Approved
Abaloparatide is a synthetic analog of PTH-related protein approved to treat osteoporosis in men and postmenopausal women at high fracture risk.
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Overview
Abaloparatide is a synthetic analog of PTH-related protein approved to treat osteoporosis in men and postmenopausal women at high fracture risk.
FDA Approval Status
Approved by the FDA for at least one medical indication (see approved uses below).
Mechanism of Action
Selectively activates the PTH1 receptor to stimulate bone formation with less bone resorption than PTH.
Current Research
ACTIVE and ACTIVExtend trials support fracture-risk reduction.
Research strength: Strong
Potential Medical Uses
- Postmenopausal osteoporosis
- Osteoporosis in men at high fracture risk
Potential Benefits
- Increased bone mineral density
- Reduced vertebral and nonvertebral fractures
Known Side Effects
- Hypercalcemia
- Orthostatic hypotension
- Dizziness
Contraindications
- Prior radiation to skeleton
- Bone malignancy
- Hypercalcemia
Drug Interactions
- Digoxin (monitor)
Administration Methods
- Subcutaneous injection daily
Half-life
~1.7 hours
Reconstitution
Prefilled pen.
Storage & Handling
Refrigerate unopened; room temperature in-use up to 30 days.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.