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ARA-290
Also known as: Cibinetide
Research / Investigational
ARA-290 (cibinetide) is an 11-amino-acid peptide derived from the tissue-protective helix B of erythropoietin, engineered to lack hematopoietic activity.
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Overview
ARA-290 (cibinetide) is an 11-amino-acid peptide derived from the tissue-protective helix B of erythropoietin, engineered to lack hematopoietic activity.
FDA Approval Status
Not approved by the FDA. Investigational or intended for research purposes only.
Mechanism of Action
Activates the innate repair receptor (heteromer of EPOR and CD131) to reduce inflammation and support repair.
Current Research
Phase II trials in sarcoid small-fiber neuropathy and diabetic neuropathy.
Research strength: Moderate
Potential Medical Uses
- Investigational only
Potential Benefits
- Reported improvement in neuropathic pain and small-fiber function
Known Side Effects
- Injection-site reactions
- Overall well tolerated in trials
Contraindications
- Pregnancy
Drug Interactions
- Not well characterized
Administration Methods
- Subcutaneous injection
Half-life
~2 minutes (rapid tissue distribution)
Reconstitution
Bacteriostatic water.
Storage & Handling
Refrigerated.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.