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Corticotropin
Also known as: ACTH / Acthar Gel
FDA-Approved
Repository corticotropin injection is a purified porcine ACTH preparation approved for multiple inflammatory and autoimmune indications, including infantile spasms.
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Overview
Repository corticotropin injection is a purified porcine ACTH preparation approved for multiple inflammatory and autoimmune indications, including infantile spasms.
FDA Approval Status
Approved by the FDA for at least one medical indication (see approved uses below).
Mechanism of Action
Stimulates the adrenal cortex to secrete cortisol, corticosterone, aldosterone, and androgens.
Current Research
Long clinical history; RCT support in infantile spasms.
Research strength: Strong
Potential Medical Uses
- Infantile spasms
- MS relapses
- Various rheumatologic and dermatologic conditions
Potential Benefits
- Endogenous steroid production
- Alternative when synthetic steroids fail
Known Side Effects
- Hypertension
- Hyperglycemia
- Immunosuppression
- Adrenal suppression
Contraindications
- Scleroderma
- Osteoporosis
- Systemic fungal infection
- Ocular herpes
Drug Interactions
- Diabetes medications
- Vaccines
Administration Methods
- Intramuscular or subcutaneous injection
Half-life
~15 minutes (native ACTH); prolonged in gel form
Reconstitution
Supplied as gel; no reconstitution.
Storage & Handling
Refrigerate.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.