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Degarelix
Also known as: Firmagon
FDA-Approved
Degarelix is a GnRH antagonist that rapidly suppresses testosterone in the treatment of advanced prostate cancer, without an initial testosterone flare.
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Overview
Degarelix is a GnRH antagonist that rapidly suppresses testosterone in the treatment of advanced prostate cancer, without an initial testosterone flare.
FDA Approval Status
Approved by the FDA for at least one medical indication (see approved uses below).
Mechanism of Action
Directly blocks pituitary GnRH receptors, immediately reducing LH, FSH, and testosterone.
Current Research
Head-to-head trials versus leuprolide demonstrate faster testosterone suppression.
Research strength: Strong
Potential Medical Uses
- Advanced prostate cancer
Potential Benefits
- No testosterone flare
- Rapid castrate levels within days
Known Side Effects
- Hot flashes
- Injection-site reactions
- Weight gain
- Hepatic enzyme elevations
Contraindications
- Hypersensitivity
Drug Interactions
- QT-prolonging agents
Administration Methods
- Subcutaneous injection monthly
Half-life
~53 days (depot)
Reconstitution
Reconstitute per label immediately before injection.
Storage & Handling
Room temperature.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.