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Evidence-based · Educational only•
36+ Peptides indexed•
Free research library•
Free newsletter — subscribe below•
★ = FDA-approved medical indication•
Not medical advice — always consult a clinician•
Peptide Knowledge Center
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Desmopressin

Also known as: DDAVP
FDA-Approved

Desmopressin is a synthetic analog of vasopressin selective for the V2 receptor.

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Overview

Desmopressin is a synthetic analog of vasopressin selective for the V2 receptor.

FDA Approval Status

Approved by the FDA for at least one medical indication (see approved uses below).

Mechanism of Action

V2 receptor agonism in renal collecting ducts; increases von Willebrand factor release.

Current Research

Well-established.
Research strength: Strong

Potential Medical Uses

  • Central diabetes insipidus
  • Primary nocturnal enuresis
  • Mild hemophilia A
  • von Willebrand disease type 1

Potential Benefits

  • Reduces urine output
  • Increases clotting factor activity

Known Side Effects

  • Hyponatremia
  • Headache
  • Nausea

Contraindications

  • Hyponatremia
  • Severe renal impairment

Drug Interactions

  • SSRIs, NSAIDs (hyponatremia risk)

Administration Methods

  • Oral
  • Intranasal
  • Injection

Half-life

~3 hours

Reconstitution

Commercial formulations.

Storage & Handling

Refrigerate injectable/nasal per label.

References & Sources

Frequently Asked Questions

Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.