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Enfuvirtide
Also known as: Fuzeon
FDA-Approved
Enfuvirtide is a 36-amino-acid peptide approved as part of combination antiretroviral therapy in treatment-experienced HIV patients.
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Overview
Enfuvirtide is a 36-amino-acid peptide approved as part of combination antiretroviral therapy in treatment-experienced HIV patients.
FDA Approval Status
Approved by the FDA for at least one medical indication (see approved uses below).
Mechanism of Action
Binds gp41 to block conformational changes required for HIV-1 fusion with CD4 cells.
Current Research
TORO-1/2 trials support efficacy in resistant HIV.
Research strength: Strong
Potential Medical Uses
- HIV-1 infection (combination therapy)
Potential Benefits
- Activity against multi-drug-resistant HIV
Known Side Effects
- Injection-site reactions (nearly universal)
- Pneumonia risk
- Hypersensitivity
Contraindications
- Hypersensitivity
Drug Interactions
- Few systemic drug interactions
Administration Methods
- Subcutaneous injection twice daily
Half-life
~3.8 hours
Reconstitution
Reconstitute with sterile water, gently swirl (do not shake).
Storage & Handling
Room temperature powder; refrigerate reconstituted; use within 24 hours.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.