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Evidence-based · Educational only•
36+ Peptides indexed•
Free research library•
Free newsletter — subscribe below•
★ = FDA-approved medical indication•
Not medical advice — always consult a clinician•
Peptide Knowledge Center
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Leuprolide

Also known as: Lupron
FDA-Approved

Leuprolide is a GnRH agonist that suppresses gonadotropin release after initial stimulation.

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Overview

Leuprolide is a GnRH agonist that suppresses gonadotropin release after initial stimulation.

FDA Approval Status

Approved by the FDA for at least one medical indication (see approved uses below).

Mechanism of Action

Continuous GnRH receptor stimulation desensitizes pituitary, lowering LH/FSH and sex hormones.

Current Research

Long clinical history.
Research strength: Strong

Potential Medical Uses

  • Prostate cancer
  • Endometriosis
  • Uterine fibroids
  • Central precocious puberty

Potential Benefits

  • Effective hormonal suppression

Known Side Effects

  • Hot flashes
  • Bone loss
  • Sexual dysfunction

Contraindications

  • Pregnancy
  • Hypersensitivity

Drug Interactions

  • QT-prolonging drugs

Administration Methods

  • Subcutaneous or IM depot

Half-life

~3 hours (drug); effect prolonged by depot

Reconstitution

Depot kits.

Storage & Handling

Room temperature typically per label.

References & Sources

Frequently Asked Questions

Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.