All peptides
Linaclotide
Also known as: Linzess
FDA-Approved
Linaclotide is a 14-amino-acid peptide agonist of intestinal guanylate cyclase-C approved for irritable bowel syndrome with constipation and chronic idiopathic constipation.
Buy Linaclotide on American Peptides
Affiliate link — we may earn a commission at no extra cost to you.
Overview
Linaclotide is a 14-amino-acid peptide agonist of intestinal guanylate cyclase-C approved for irritable bowel syndrome with constipation and chronic idiopathic constipation.
FDA Approval Status
Approved by the FDA for at least one medical indication (see approved uses below).
Mechanism of Action
GC-C activation increases intracellular cGMP, driving chloride and bicarbonate secretion and accelerating transit.
Current Research
Multiple Phase III trials.
Research strength: Strong
Potential Medical Uses
- IBS-C in adults
- Chronic idiopathic constipation
- Functional constipation in pediatrics (per label)
Potential Benefits
- Improved bowel frequency
- Abdominal pain reduction
Known Side Effects
- Diarrhea
- Abdominal pain
- Flatulence
Contraindications
- Pediatric patients under 2
- Known/suspected mechanical GI obstruction
Drug Interactions
- Minimal systemic absorption; few interactions
Administration Methods
- Oral capsule daily on empty stomach
Half-life
Not systemically measurable (gut-restricted)
Reconstitution
N/A (oral).
Storage & Handling
Room temperature, protected from moisture.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.