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Melanotan-1
Also known as: Afamelanotide
FDA-Approved
Afamelanotide (Melanotan-1) is a longer-acting analog of alpha-melanocyte-stimulating hormone approved to prevent phototoxic reactions in EPP.
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Overview
Afamelanotide (Melanotan-1) is a longer-acting analog of alpha-melanocyte-stimulating hormone approved to prevent phototoxic reactions in EPP.
FDA Approval Status
Approved by the FDA for at least one medical indication (see approved uses below).
Mechanism of Action
Agonist at melanocortin-1 receptor, stimulating eumelanin synthesis.
Current Research
Approved by FDA (Scenesse) for EPP; ongoing research for vitiligo.
Research strength: Strong
Potential Medical Uses
- Erythropoietic protoporphyria (EPP)
Potential Benefits
- Increased skin melanin
- Reduced phototoxic pain in EPP
Known Side Effects
- Nausea
- Skin darkening
- Injection-site reactions
- Flushing
Contraindications
- Melanoma or non-melanoma skin cancer history
- Liver impairment
Drug Interactions
- Photosensitizing drugs (theoretical)
Administration Methods
- Subcutaneous implant (approved product)
Half-life
~30 minutes (peptide); implant releases over ~2 months
Reconstitution
Prefilled implant (approved product).
Storage & Handling
Refrigerated per label.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.