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PE-22-28
Also known as: Spadin analog
Research / Investigational
PE-22-28 is a shorter analog of spadin that blocks the TREK-1 potassium channel, an emerging target in depression research.
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Overview
PE-22-28 is a shorter analog of spadin that blocks the TREK-1 potassium channel, an emerging target in depression research.
FDA Approval Status
Not approved by the FDA. Investigational or intended for research purposes only.
Mechanism of Action
TREK-1 potassium channel inhibitor.
Current Research
Rodent models show antidepressant-like effects with rapid onset.
Research strength: Preliminary
Potential Medical Uses
- Investigational only
Potential Benefits
- Rapid antidepressant-like effect in animals
Known Side Effects
- Unknown long-term human safety
Contraindications
- Pregnancy
Drug Interactions
- Not well characterized
Administration Methods
- Subcutaneous or intranasal (research)
Half-life
Not well characterized
Reconstitution
Bacteriostatic water.
Storage & Handling
Refrigerated.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.