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Plecanatide
Also known as: Trulance
FDA-Approved
Plecanatide is an analog of the endogenous peptide uroguanylin approved for chronic idiopathic constipation and IBS-C.
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Overview
Plecanatide is an analog of the endogenous peptide uroguanylin approved for chronic idiopathic constipation and IBS-C.
FDA Approval Status
Approved by the FDA for at least one medical indication (see approved uses below).
Mechanism of Action
pH-dependent GC-C agonism increases fluid secretion and transit.
Current Research
Pivotal Phase III trials.
Research strength: Strong
Potential Medical Uses
- Chronic idiopathic constipation
- IBS-C
Potential Benefits
- Improved stool frequency and consistency
Known Side Effects
- Diarrhea
Contraindications
- Pediatric under 6
- Suspected mechanical GI obstruction
Drug Interactions
- Minimal
Administration Methods
- Oral tablet daily
Half-life
Minimal systemic exposure
Reconstitution
N/A (oral).
Storage & Handling
Room temperature.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.