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Pramlintide
Also known as: Symlin
FDA-Approved
Pramlintide is a synthetic analog of the beta-cell hormone amylin, approved as an adjunct to mealtime insulin in type 1 and insulin-using type 2 diabetes.
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Overview
Pramlintide is a synthetic analog of the beta-cell hormone amylin, approved as an adjunct to mealtime insulin in type 1 and insulin-using type 2 diabetes.
FDA Approval Status
Approved by the FDA for at least one medical indication (see approved uses below).
Mechanism of Action
Slows gastric emptying, suppresses postprandial glucagon, and promotes satiety.
Current Research
Multiple pivotal trials support A1C reduction and modest weight loss.
Research strength: Strong
Potential Medical Uses
- Type 1 diabetes with insulin
- Insulin-using type 2 diabetes
Potential Benefits
- Reduced postprandial hyperglycemia
- Modest weight loss
Known Side Effects
- Severe hypoglycemia (with insulin)
- Nausea
- Anorexia
Contraindications
- Gastroparesis
- Hypoglycemia unawareness
Drug Interactions
- Insulin (reduce prandial dose)
- Anticholinergics
Administration Methods
- Subcutaneous injection before meals
Half-life
~48 minutes
Reconstitution
Prefilled pen.
Storage & Handling
Refrigerate unopened; in-use room temperature per label.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.