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Evidence-based · Educational only•
36+ Peptides indexed•
Free research library•
Free newsletter — subscribe below•
★ = FDA-approved medical indication•
Not medical advice — always consult a clinician•
Peptide Knowledge Center
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Semaglutide

Also known as: Ozempic / Wegovy / Rybelsus
FDA-Approved

Semaglutide is a long-acting GLP-1 receptor agonist approved for type 2 diabetes, chronic weight management, and cardiovascular risk reduction.

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Overview

Semaglutide is a long-acting GLP-1 receptor agonist approved for type 2 diabetes, chronic weight management, and cardiovascular risk reduction.

FDA Approval Status

Approved by the FDA for at least one medical indication (see approved uses below).

Mechanism of Action

Activates GLP-1 receptors: enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, reduces appetite.

Current Research

Large randomized trials (SUSTAIN, STEP, SELECT) establish glycemic, weight, and cardiovascular benefits.
Research strength: Strong

Potential Medical Uses

  • Type 2 diabetes
  • Chronic weight management (BMI ≥30 or ≥27 with comorbidity)
  • CV risk reduction

Potential Benefits

  • A1C reduction
  • Weight loss
  • Reduced MACE in trials

Known Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Pancreatitis (rare)
  • Gallbladder disease

Contraindications

  • Personal/family history of medullary thyroid carcinoma
  • MEN 2
  • Prior hypersensitivity

Drug Interactions

  • Insulin/sulfonylureas (hypoglycemia risk)
  • Oral medications (delayed absorption)

Administration Methods

  • Subcutaneous injection weekly
  • Oral tablet (Rybelsus, daily)

Half-life

~7 days

Reconstitution

Prefilled pen; no reconstitution required.

Storage & Handling

Refrigerate unopened pens; in-use pens up to 56 days per label.

References & Sources

Frequently Asked Questions

Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.