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Teduglutide
Also known as: Gattex
FDA-Approved
Teduglutide is a recombinant GLP-2 analog approved for adults and children with short bowel syndrome dependent on parenteral support.
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Overview
Teduglutide is a recombinant GLP-2 analog approved for adults and children with short bowel syndrome dependent on parenteral support.
FDA Approval Status
Approved by the FDA for at least one medical indication (see approved uses below).
Mechanism of Action
Activates intestinal GLP-2 receptors, increasing villus height and enhancing nutrient absorption.
Current Research
Pivotal STEPS trials support reduced parenteral support requirements.
Research strength: Strong
Potential Medical Uses
- Short bowel syndrome
Potential Benefits
- Reduced parenteral nutrition dependence
Known Side Effects
- Abdominal pain
- Nausea
- Injection-site reactions
- Colorectal polyps (screen)
Contraindications
- Active GI malignancy
Drug Interactions
- Oral medications (increased absorption possible)
Administration Methods
- Subcutaneous injection daily
Half-life
~2 hours
Reconstitution
Supplied with sterile diluent per label.
Storage & Handling
Refrigerate.
References & Sources
Frequently Asked Questions
Information on this page is educational and general in nature. It is not medical advice. Consult a qualified healthcare professional before making any medical decisions.